To amplify Aniket's last suggestion...instead of changing materials,  just change the material property.

For example Steel and Aluminum have very different values of Young's Modulus. Instead of changing the material from Steel to Aluminum, just have one material called EveryMaterial but make Young's Modulus a ParameterHere is another example.

Now you can have a Parameter Set under all your models and you can go through the combinations in a spreadsheet.

Do the same with the loads. Make the value a Parameter. Then you can manage it all in the Parameter Design Point spreadsheet.