When you have 5 different scenarios the logical approach would be to find out what combination of these cases gives you the worst case scenario/ maximum load on your components. Right? Lets say you want to design the front wheel hub of a car. The maximum loading condition on one of the front wheel hub would be when the car is on a down hill, cornering and braking at the same time right. Designing the hub with this condition would give you the highest safety margin. Once you identify this condition, you could perform a structural analysis accordingly and use a fatigue tool to find out its life.
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