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The incompletes suggest something has failed in the flow solver too. We know the mesh isn't ideal given the jump in cell size. We also know it's a symmetrical domain. Chop the domain down to a quarter & remesh with a more uniform size. Use tets if necessary, but avoid the jump in size. This will allow you to either refine the mesh (same cell count but smaller volume) or speed up the simulation (same-ish resolution as it's a smaller domain). The injection will report several lost parcels but that can be ignored as they're just being released in the 3/4 that's not there.
And use either Workbench (Ansys) Meshing or Fluent Meshing. Or tets in ICEM CFD, avoid the O-grid as that's possibly what is causing the problem as the cell size jumps moving away from the central block.