George Karnos
Ansys Employee

Try the following:
Close All ANSYS Aqpplications.

Open Windows file explorer and type in the following in the addres line:

%APPDATA%\Ansys
This should take you to 

C:\Users\\AppData\Roaming\Ansys

There will be a directory named:

v221 (for 2022 R1)
rename this to v221.old
now try to restart

If this doesn't work, there will be a directory named WorkbenchLogs
under %TEMP%

Check the log files in there for errors.