George Karnos
Ansys Employee

What is the PATH to where you are saving your projects?
What happens if you create a directory named:  C:\test
Then try to save and then open a project from there?
Also, what happens if you open Workbench by right-clicking on Workbench and chosing 
more->run as administrator

One more thought, do you have a virus scanner active?
Any logs show virus scanning interferrence?