DrAmine
Ansys Employee

The error suggests that users are running from non-standard user account an something odd happened due your system update, or your profile is not defined anymore or anything else which I cannot think about now. Check with your IT.

Worth verifiying if below env variables are setup for your machine:

HOMEDRIVE (typically C:)

HOMEPATH (typically \Users\%USERNAME%)

USERNAME (your username)

and 

USERPROFILE (typically C:\Users\%USERNAME%)