The error suggests that users are running from non-standard user account an something odd happened due your system update, or your profile is not defined anymore or anything else which I cannot think about now. Check with your IT.
Worth verifiying if below env variables are setup for your machine:
HOMEDRIVE (typically C:)
HOMEPATH (typically \Users\%USERNAME%)
USERNAME (your username)
and
USERPROFILE (typically C:\Users\%USERNAME%)
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