You can import the excel file into external data and map it to structural model in Mechanical using "Imported load". The excel file can have X , Y, Z coordinate and the pressure value.
Example schematic:
Double click on the "set up" cell in external data and select the excel file and specify the details. You should see a preview of your data
Sample preview that shows tempearute import
You can then use Imported load inside Mechanical and apply the pressure on geometry
Check help section: Imported Load (Group) (ansys.com)
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