John Doyle
Ansys Employee

I am not sure I understand your question or your objective. 

Elements with forces and pressure loads applied to them are interpreted as being part of boundary conditions and are excluded from the Topology Optimization analysis by default.  This means that these elements will NOT be eligible for removal during the optimization run.  In general, this is usually a good thing as it prevents elements that are potentially part of the primary load path from being removed.  You can overide the default, but it might cause convergence trouble.  Kind of like kicking the legs out from under a table.