Short answer, yes.
Longer answer we have a few optimisation tools within Ansys, some in Fluent itself, others linked into WorkBench or Optislang. There are then a few extra tools that are available via partnerships rather than being owned by Ansys.
However..... With a complex system I'd run a model first to see what's going on and to understand the flow field & temperature within the solid/fluid bits. Then look at what you can (and can't) alter. Adjoint might be a good idea to start with.
Have a look in Learning (left, near top) and in Fluent's Help system for tutorials and then the User's Guide to see what's available.
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