Rob
Ansys Employee

If you take the inlet pressure and (I assume) set outlet pressure you get a bulk dP value. If you set interior surfaces on the holes at the geometry stage, and label each with a unique value you can also get those values. It depends on what you need. 

You may want to look up "effective area", it was a method I used for my PhD to help figure out a dP against flow for a gas turbine combustor where I was effectively altering the port size of the primary inlet using a fluidic device. As my thesis is public domain I can mention the approach.