Hello,
It would be easier for the software to handle the geometry if it was built in the software with geometry objects like Spheres instead of importing a polygon with a large number of vertices.
That being said, even if you were able to build the geometry, running the simulation would require a large amount of computational resources due to the large simulation region small feature sizes. I can't really say how much unless you give a scale for these objects in your simulation, but it could easily require ~100s of GB of memory.
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