For improving mesh after prism generation, you can use Fluent Meshing.
In WB Meshing please export .msh file from File --> Export
Start Fluent in mehsing mode. Read .msh file. Go to Mesh --> Auto Node Move.
Select all boundary zones and click apply.
On prism layer thickness: it depends on what y+ you are targeting, what velocities you are using etc.
In general 5 layers of prism layers should be enough for regular flows. Please try to reach aspect ratio of 5-10 for first prism layer.
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