I know that this is an old thread, but I am having the same issue now since I upgraded to 2021 R2.

Is there a setting in Spaceclaim that I have to adjust to accept input from a spacemouse?

I have used the spacemouse on older versions without a hitch, but now on this new computer and new version, I cannot get it to connect. The spacemouse works fine using its own viewer and while navigating chrome and google earth. I imported the user settings from the old versions to this version.

Thanks in advance.